By way of contrast, estimates of the daily absorption of all forms of mercury from fish and seafood is 2. Currently, Germany, Sweden and Denmark severely restrict the use of amalgams.
A "silver" filling, or dental amalgam, is not a true alloy. More than million mercury fillings are placed each year in the U. The mercury vapor from the amalgams is lipid soluble and passes readily through cell membranes and across the blood brain barrier. The vapor serves as the primary route of mercury from amalgams into the body. It is clear that amalgam mercury transfers to human tissues, accumulates with time, and presents a potential health threat.
The mercury escapes continuously during the entire life of the filling primarily in the form of vapor, ions but also abraded particles. Chewing, brushing, and the intake of hot fluids stimulates this release.
Statements made by dental authorities which claim that the amount of mercury exposure encountered by patients from dental amalgams is too small to be harmful, are contradicted by the literature. Animal studies show that radioactively labeled mercury released from ideally placed amalgam fillings appear quickly in the kidneys, brain and wall of the intestines.
The fact that mercury amalgam fillings are banned in some European countries is strong evidence of the clinical toxicity of this material. Any metal tooth restoration placed in the mouth will also produce electrogalvanic effects.
When dissimilar metals are placed in the oral cavity they exert a battery-like effect because of the electroconductivity of the saliva. The electrical current causes metal ions to go into solution at a much higher rate, thereby increasing the exposure to mercury vapor and mercury ions many fold. Gold placed in the vicinity of an amalgam restoration produces a fold increase in the release of mercury. Mercury in the central nervous system CNS causes psychological, neurological, and immunological problems in humans.
Mercury bonds very firmly to structures in the CNS through its affinity for sulfhydryl-groups on amino acids. Other studies have shown that mercury is taken up in the periphery by all nerve endings and rapidly transported inside the axon of the nerves axonal transport to the spinal cord and brainstem. Unless actively removed, mercury has an extremely long half-life of somewhere between 15 and 30 years in the CNS. Mercury Toxicity SymptomsThe overt clinical effects resulting from toxic exposure to mercury have been clearly described.
The scientific literature shows that amalgam fillings have been associated with a variety of problems such as Alzheimer's Disease, autoimmunity, kidney dysfunction, infertility, polycystic ovary syndrome, neurotransmitter imbalances, food allergies, multiple sclerosis, thyroid problems, and an impaired immune system.
Patients with many amalgam fillings will also have an increase in the prevalence of antibiotic resistant bacteria. Subclinical neuropsychological and motor control effects were also observed in dentists who had documented high mercury exposure levels. Amalgam use may also be related to fatigue, poor memory and certain psychological disorders.
There has been a recent epidemic of autism in the US and many investigators believe that this may be partially related to the increased exposure infants have had to mercury through the preservative thimerosal that was included in nearly all vaccines until recently. The nervous system is more sensitive to mercury toxicity than any other organ in the body. Mercury has recently been documented to be associated with arrhythmias and cardiomyopathies as hair analysis showed mercury levels to be 20, higher in those with these cardiac abnormalities.
How to Cite Blaurock-Busch, E. Journal of Advances in Medicine and Medical Research , 4 9 , Current Issue. J Pediatr ; Determination and metabolism of dithiol chelating agents. Isolation and identification of the mixed disulfides of meso-2,3-dimercaptosuccinic acid with Lcysteine in human urine. Behavioral effects of low-level exposure to elemental Hg among dentists. Neurotoxicol Teratol ; Kosnett MJ. Unithiol DMPS. In: Olson KR, editor.
The role of zinc and copper in autism spectrum disorders. Acta Neurobiol Exp Wars ; Urinary excretion of meso-2,3-dimercaptosuccinic acid in human subjects.
This brings up the question as to whether chelation only takes place in the kidney - a question that will be investigated. There appears to be a major species difference in the biotransformation of DMSA.
Preliminary results indicate a DMPS challenge test to detect """"""""mini-exposure"""""""" to mercury is promising. The long-term goal is to study the toxicological and pharmacological properties of these orally effective therapeutic agents so that safe chelating agents will be available for human therapy.
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