When these tiny structures don't function properly, nearly every system in the body can be affected. Mitochondrial problems are linked to a variety of diseases and conditions. Because these metabolic imbalances take place not only during migraine attacks but also may exist in between them, supplementation with CoQ10 may stabilize imbalances, potentially preventing migraines. Only a few studies have looked at coenzyme Q10 as a migraine prophylactic, but some studies suggest that they may be beneficial in preventing episodic migraines occurring in fewer than 15 days per month.
In an early study published in the journal Neurology, 43 people with episodic migraines received either milligrams mg of CoQ10 or a placebo three times a day for three months.
A review of studies reported similar findings. The review, published in Acta Neurologica Scandinavica, analyzed five studies involving a total of participants children and adults. According to the researchers, CoQ10 was able to reduce the number of attacks per month along with their duration. What it was not able to do is reduce the actual severity of the symptoms. Coenzyme Q10 has been found to have enough potential to be listed as a level C drug, meaning it is "possibly effective" for preventing episodic migraine headaches per the guidelines set by the AHS and the AAN in One thing that makes CoQ10 supplementation attractive to people with migraines is that it has few side effects, and those that have been documented have been mild.
As a nutritional supplement, coenzyme Q10 is sold as a pill, capsule, or gelcap to be taken by mouth. To ensure quality and purity, opt for brands that have been voluntarily tested and certified by an independent authority like the U. Coenzyme Q10 can also be derived from food sources, including oily fish, organ meats, and whole grains. But it would be difficult to get the recommended therapeutic amounts from food sources alone.
There are few medications known to potentially interact with coenzyme Q10 supplements. They include:. Advise your healthcare provider if you take these or any other medications before trying coenzyme Q10 to prevent migraine headaches. Coenzyme Q10 has not been established as safe during pregnancy or breastfeeding. So if you are pregnant, planning to conceive, or are breastfeeding, it is best not to take this supplement just to be safe. If you have episodic migraine headaches, taking coenzyme Q10 supplements might be a natural and effective way to prevent them.
Before taking any supplement, however, speak with your healthcare provider to ensure you can take them safely based on your individual health concerns. Once you start taking this supplement, be patient.
It may take several weeks before you notice any difference in the incidence or duration of migraine symptoms. Let your healthcare provider know if you experience any side effects, particularly fatigue, nausea, vomiting, jaundice , or any other signs of liver toxicity. Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Potential protective mechanisms of ketone bodies in migraine prevention.
Sachdev A, Marmura MJ. Join Now See All Benefits. Thank you for your patience. The participants taking CoQ10 also had fewer days with a headache and fewer days with nausea. Approximately 48 percent of those who took CoQ10 had half as many attacks during the three-month study, while this occurred in only about 14 percent of those taking a placebo. This compares with side effects of fatigue, weight gain, dry mouth, and other side effects found with other methods to prevent migraine.
It is found in meat and seafood, as well as dietary supplements, but in lower dosages. Other energy producers, such as riboflavin, which improves energy metabolism, have also been found to be useful in migraine prevention. At the moment there is a need for more research into whether these have any benefit for migraine.
For most people, most supplements are unlikely to cause any harm. If you notice a change in your symptoms or other potential side effects speak to your GP. As with other preventive treatments for migraine it is likely to take time to see if it is helping usually weeks. It may take up to three months to see the full benefit. The available evidence suggests supplements are most effective in less severe presentations of migraine.
They may be more effective for people with episodic migraine. We can help with questions about non-drug treatments for migraine. Our monthly ebulletin is the best way to find out about the latest migraine treatments, migraine events in your area, get help in managing your condition and learn about getting involved in our work.
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